Tretinoin Cream is our most popular anti-ageing product. UK and Worldwide shipping.

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Clinically proven

cosMIENCE sell cosmetics and beauty products with active ingredients which clinical studies have proven their effectiveness.


Tretinoin (also known as Retin a) is a retinoid and derivative of vitamin a patented over 60 years ago and initially developed to treat acne. However, there have been many studies since this time that have been carried out to test tretinoin’s efficacy as an anti-ageing treatment. Such as reducing fine lines, wrinkles, and age spots, improving sun-damaged skin and increasing skin elasticity and collagen production. These studies have unanimously shown that when applied topically in cream or gel form, tretinoin is a very effective treatment for treating these issues on the face. It encourages the skin cells to renew faster; older dead skin cells are replaced by newer undamaged skin cells more frequently. Therefore, brighter, younger-looking skin is visible.

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Tazarotene (also known as Tazorac) is also from the retinoid family and a derivative of vitamin A. Originally developed to treat acne and psoriasis over 20 years ago. However, studies have shown tazarotene to be an effective anti-ageing treatment when applied topically in cream or gel form. For example, tazarotene reduced fine lines, wrinkles, and age spots and improved sun damaged skin. Studies also showed collagen production in the treated skin also increased.

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Bimatoprost (also known as Careprost) was developed over 20 years ago as a treatment for glaucoma when applied to the eye as eyedrops. However, studies have been carried out which have identified bimatoprost as an effective treatment to grow longer, thicker eyelashes when applied directly to the base of eyelashes with a brush. It’s also shown to be effective at growing thicker eyebrows when applied to eyebrows.

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Minoxidil developed over 40 years ago was initially an oral medication taken to treat high blood pressure by opening blood vessels to increase blood flow. Doctors observed patients who took minoxidil for high blood pressure and suffered from hair loss and thinning hair began to have fuller, thicker heads of hair. After further investigations, a topical minoxidil solution was developed and applied directly onto the scalp. After trials confirmed topical minoxidil does improve hair growth, the new hair loss treatment was released. When applied directly onto the scalp, blood flow to the hair follicles is increased, the growth phase changes from the resting to the growth phase and a thicker, fuller head of hair is the result.

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